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Atlantic horseshoe crab Limulus polyphemus. Limulus amebocyte lysate (LAL) is an aqueous extract of motile blood cells from the Atlantic horseshoe crab Limulus polyphemus.LAL reacts with bacterial endotoxins such as lipopolysaccharides (LPS), which are components of the bacterial capsule, the outermost membrane of cell envelope of gram-negative bacteria.
The horseshoe crabs are valuable because their blood can be manufactured into limulus amebocyte lysate, or LAL, that is used to detect pathogens in indispensable medicines such as injectable ...
The horseshoe crabs themselves are also declining in some of their range. They are valuable because of their blue blood, which can be manufactured to detect pathogens in critical medicines such as ...
Horseshoe crabs primarily live at the water's bottom but they can swim if needed. In the modern day, their distribution is limited, only found along the east coasts of North America and South Asia. Horseshoe crabs are often caught for their blood, which contains Limulus amebocyte lysate, a chemical used to detect bacterial endotoxins.
A protein from horseshoe crab blood is also under investigation as a novel antibiotic. [30] Procuring the raw materials for LAL testing involves collecting and bleeding horseshoe crabs from wild populations. Horseshoe crabs are returned to the ocean after bleeding, however, there is a level of mortality and sub-lethal impact involved.
The blood is blue because it contains a copper-based respiratory pigment called hemocyanin. Aside from their blood, horseshoe crab populations occupy an important ecological niche in estuarine and ...
The group has hardly changed in appearance in hundreds of millions of years; the modern horseshoe crabs look almost identical to prehistoric genera and are considered to be living fossils. The most notable difference between ancient and modern forms is that the abdominal segments in present species are fused into a single unit in adults.
Similarly to some of the white blood cells of vertebrates, in many species amebocytes are found in the blood or body fluid (e.g. as the blood cells of Limulus, the horseshoe crab) [1] and play a role in the defense of the organism against pathogens. Depending on the species, an amebocyte may also digest and distribute food, dispose of wastes ...