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  2. Infliximab - Wikipedia

    en.wikipedia.org/wiki/Infliximab

    Common side effects include infections, acute infusion reactions, and abdominal pain. [23] Infliximab is a chimeric monoclonal antibody biologic. It seems to work by binding to and neutralizing TNF-α, preventing it from interacting with its receptors on the cell. [23] TNF-α is a chemical messenger and a key part of the autoimmune reaction.

  3. Biological therapy for inflammatory bowel disease - Wikipedia

    en.wikipedia.org/wiki/Biological_therapy_for...

    Infliximab works by binding to TNF, stopping its inflammatory effects. It was initially used for the treatment of Crohn's disease and it became the first FDA approved TNF inhibitor in 1998. [ 16 ] Infliximab as well as other TNF inhibitors like adalimumab , certolizumab , and golimumab are currently the most common biologics used in the ...

  4. TNF inhibitor - Wikipedia

    en.wikipedia.org/wiki/TNF_inhibitor

    A TNF inhibitor is a pharmaceutical drug that suppresses the physiologic response to tumor necrosis factor (TNF), which is part of the inflammatory response.TNF is involved in autoimmune and immune-mediated disorders such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, psoriasis, hidradenitis suppurativa and refractory asthma, so TNF inhibitors may be used in their ...

  5. Management of Crohn's disease - Wikipedia

    en.wikipedia.org/wiki/Management_of_Crohn's_disease

    Infliximab has found utility as follows: Induction and maintenance of remission for people with Crohn's disease [14] Maintenance for fistulizing Crohn's disease [15] Side effects of infliximab, like other immunosuppressants of the TNF class, can be serious and potentially fatal, and infliximab carries an FDA black-box warning on the label.

  6. Pfizer's bladder cancer therapy meets main goal in late-stage ...

    www.aol.com/news/pfizers-bladder-cancer-therapy...

    The antibody treatment, sasanlimab, in combination with Bacillus Calmette-Guérin (BCG) vaccine met the main goal of the study in patients with high-risk non-muscle invasive bladder cancer (NMIBC ...

  7. List of therapeutic monoclonal antibodies - Wikipedia

    en.wikipedia.org/wiki/List_of_therapeutic...

    reduction of side effects of cardiac surgery: Pidilizumab [40] mab: humanized: PD-1: cancer and infectious diseases Pinatuzumab vedotin [40] mab: humanized: CD22: cancer Pintumomab: mab: mouse: adenocarcinoma antigen: adenocarcinoma (imaging) Placulumab [15] mab: human: TNF: pain and inflammatory diseases Pozelimab [35] Veopoz: mab: human: C5 ...

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