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Uterine serous carcinoma is a malignant form of serous tumor that originates in the uterus. It is an uncommon form of endometrial cancer that typically arises in postmenopausal women. It is typically diagnosed on endometrial biopsy , prompted by post-menopausal bleeding .
Rarely, serous tumors arise from within the uterus, notably uterine serous carcinoma, which typically arises in postmenopausal women. Rarely, serous tumors arise from other parts of the peritoneum, including serous primary peritoneal carcinomas. Even more rarely they arise in other body locations, such as the lungs. [1]
Serous carcinoma is a Type II endometrial tumor that makes up 5–10% of diagnosed endometrial cancer and is common in postmenopausal women with atrophied endometrium and black women. Serous endometrial carcinoma is aggressive and often invades the myometrium and metastasizes within the peritoneum (seen as omental caking ) or the lymphatic system.
Endometrial carcinomas originate from cells in the glands of the endometrium (uterine lining). These include the common and readily treatable well-differentiated endometrioid adenocarcinoma, as well as the more aggressive uterine papillary serous carcinoma and uterine clear-cell carcinoma.
The common Müllerian origin of the Fallopian tubes, uterus, cervix, and upper vagina has resulted in the proposal that peritoneal high-grade serous carcinoma is a spectrum of a single disease. [22] Relevant animal models of HGSC can only be developed when the cell origin is properly understood.
In an interview with TMZ, Dr. George Crawford, a surgeon who hasn't treated Princess Kate, speculated that Middleton may have one of two types of cancers: uterine cancer or ovarian cancer.
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