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Physical examination reviews clinical symptoms like degree of jaundice, vital signs and sensations of pain, further followed by urine tests, blood analysis and imaging. [3] [4] The degree of yellowish staining of the conjunctiva and skin in jaundice is proportional to hyperbilirubinemia to some extent. [6]
Hepatic jaundice is caused by abnormal liver metabolism of bilirubin. [26] The major causes of hepatic jaundice are significant damage to hepatocytes due to infectious, drug/medication-induced, autoimmune etiology, or less commonly, due to inheritable genetic diseases. [27] The following is a partial list of hepatic causes to jaundice: [28]
Although unpleasant, this was not dangerous and the discolouration eventually faded over time with no long-term health effects. [5] A more serious consequence of working with TNT powder was liver toxicity, which led to anaemia and jaundice. This condition, known as "toxic jaundice", gave the skin a different type of yellow hue.
Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune disease of the liver. [1] [2] [3] It results from a slow, progressive destruction of the small bile ducts of the liver, causing bile and other toxins to build up in the liver, a condition called cholestasis.
12. Fever, shivering, and feeling unwell. Such symptoms are uncommon pancreatic cancer symptoms, but aren’t unheard of and may be either linked to the cancer itself, or possibly an infection ...
Hyperbilirubinemia can cause a yellowing of the skin called jaundice depending on the level of bilirubin in the blood. [3] Additional symptoms of hyperbilirubinemia include darker urine (bilirubinuria) due to increased unconjugated bilirubin removed from the body in urine.
Hemolytic jaundice, also known as prehepatic jaundice, is a type of jaundice arising from hemolysis or excessive destruction of red blood cells, when the byproduct bilirubin is not excreted by the hepatic cells quickly enough. [1]
Acute liver failure is the appearance of severe complications rapidly after the first signs (such as jaundice) of liver disease, and indicates that the liver has sustained severe damage (loss of function of 80–90% of liver cells).