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Indole-3-carbaldehyde (I3A), also known as indole-3-aldehyde and 3-formylindole, is a metabolite of dietary L-tryptophan which is synthesized by human gastrointestinal bacteria, particularly species of the Lactobacillus genus.
Indole-3-carboxylate decarboxylase (EC 4.1.1.92) is an enzyme with systematic name indole-3-carboxylate carboxy-lyase. [1] This enzyme catalyses the following chemical reaction. indole-3-carboxylate indole + CO 2. This enzyme is activated by Zn 2+, Mn 2+ or Mg 2+.
In addition to the light- or H 2 O 2-induced formation of FICZ, a number of other enzymatic pathways have been identified to convert Trp to FICZ via the precursor I3A. [2] [3] Oxidative deamination of Trp by aromatic amino acid aminotransferases (ArAT) or L-amino oxidases (LAAO), one of which is the IL4-inducible enzyme IL4I1, converts Trp to indole-3-pyruvate, which after decarboxylation ...
Indole is an organic compound with the formula C 6 H 4 CCNH 3. Indole is classified as an aromatic heterocycle. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered pyrrole ring. Indoles are derivatives of indole where one or more of the hydrogen atoms have been replaced by substituent groups.
The enzyme indolepyruvate decarboxylase (EC 4.1.1.74) catalyzes the chemical reaction 3-(indol-3-yl)pyruvate ⇌ {\displaystyle \rightleftharpoons } 2-(indol-3-yl)acetaldehyde + CO 2 This enzyme belongs to the family of lyases , specifically the carboxy-lyases, which cleave carbon-carbon bonds.
3-(4-Carboxybenzoyl)quinoline-2-carboxaldehyde (CBQCA) is a fluorogenic amine labeling dye that is not fluorescent itself, but covalently reacts with primary amines to form fluorescent products. [1] It was first reported in 1991. [2] CBQCA is largely used in the context of quantifying peptides or proteins.
Indole-3-acetaldehyde is a substrate for retina-specific copper amine oxidase, aldehyde dehydrogenase X (mitochondrial), amine oxidase B, amiloride-sensitive amine oxidase, aldehyde dehydrogenase (mitochondrial), fatty aldehyde dehydrogenase, 4-trimethylaminobutyraldehyde dehydrogenase, aldehyde dehydrogenase (dimeric NADP-preferring), aldehyde ...
L. maculans metabolizes brassinin, an important phytoalexin produced by Brassica species, into indole-3-carboxaldehyde and indole-3-carboxylic acid. Virulent isolates proceed through the (3-indolylmethyl)dithiocarbamate S -oxide intermediate, [ 31 ] while avirulent isolates first convert brassinin to N -acetyl-3-indolylmethylamine and 3 ...