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Perioral dermatitis has a tendency to occur on the drier parts of the face and can be aggravated by drying agents including topical benzoyl peroxide, tretinoin and lotions with an alcohol base. [8] Reports of perioral dermatitis in renal transplant recipients treated with oral corticosteroids and azathioprine have been documented. [5]
Common side effects include nausea, a metallic taste, loss of appetite, and headaches. [10] Occasionally seizures or allergies to the medication may occur. [ 10 ] Some state that metronidazole should not be used in early pregnancy , while others state doses for trichomoniasis are safe.
[4] [7] Minocycline is also used for the treatment of acne and rheumatoid arthritis. [7] [3] It is taken by mouth or applied to the skin. [4] [3] Common side effects include nausea, diarrhea, dizziness, allergic reactions, and kidney problems. [4] Serious side effects may include anaphylaxis, a lupus-like syndrome, and easy sunburning. [4]
[1] [2] It contains the three antibiotics neomycin, polymyxin B, and bacitracin. [1] It is for topical use. [3] [4] Possible side effects include itchiness and skin rash, [5] and in rare cases hearing loss. [5] It is relatively broad spectrum, being effective against both Gram-negative and Gram-positive bacteria. [2]
Additionally, it has been used for acne, dermatitis herpetiformis, and various other skin conditions. [5] Dapsone is available both topically and by mouth. [6] Severe side effects may include a decrease in blood cells, red blood cell breakdown especially in those with glucose-6-phosphate dehydrogenase deficiency (G-6-PD), or hypersensitivity. [4]
Side effects may only last for a short time and then go away. Side effects can be relieved in some cases with non pharmacological treatment. [4] Some side effects require treatment to correct potentially serious and sometimes fatal reactions to penicillin. Penicillin has not been found to cause birth defects. [5]
Sirolimus treatment was applied in several different formulations (ointment, gel, solution, and cream), ranging from 0.003 to 1% concentrations. Reported adverse effects included one case of perioral dermatitis, one case of cephalea, and four cases of irritation. [28] In April 2022, sirolimus was approved by the FDA for treating angiofibromas. [29]
Oral antibiotics are the recommended first-line treatment for perianal streptococcal dermatitis. [1] Perianal streptococcal dermatitis does not resolve on its own. [22] The treatment of choice for oral antibiotics include "penicillin V, azithromycin, clarithromycin, clindamycin, erythromycin, penicillinase-resistant penicillin, or cephalosporins."