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Biological applications of bifurcation theory provide a framework for understanding the behavior of biological networks modeled as dynamical systems.In the context of a biological system, bifurcation theory describes how small changes in an input parameter can cause a bifurcation or qualitative change in the behavior of the system.
The fluorochrome-based TUNEL assay applicable for flow cytometry, combining the detection of DNA strand breaks with respect to the cell cycle-phase position, was originally developed by Gorczyca et al. [4] Concurrently, the avidin-peroxidase labeling assay applicable for light absorption microscope was described by Gavrieli et al. [5] Since 1992 the TUNEL has become one of the main methods for ...
In 1970, Jacques Monod, in Chance and Necessity, an Essay on the Natural Philosophy of Modern Biology, [6] suggested teleonomy as a key feature that defines life: Rather than reject this [goal-directedness] idea (as certain biologists have tried to do) it is indispensable to recognise that it is essential to the very definition of living beings.
The analysis of biological networks with respect to diseases has led to the development of the field of network medicine. [2] Recent examples of application of network theory in biology include applications to understanding the cell cycle [ 3 ] as well as a quantitative framework for developmental processes. [ 4 ]
Cap analysis of gene expression (CAGE) is a gene expression technique used in molecular biology to produce a snapshot of the 5′ end of the messenger RNA population in a biological sample (the transcriptome).
A biological network is a method of representing systems as complex sets of binary interactions or relations between various biological entities. [1] In general, networks or graphs are used to capture relationships between entities or objects. [1]
The current definition of an overlapping gene varies significantly between eukaryotes, prokaryotes, and viruses. [2] In prokaryotes and viruses overlap must be between coding sequences but not mRNA transcripts, and is defined when these coding sequences share a nucleotide on either the same or opposite strands.
The DNA template labeled at the 3' or 5' end, depending on the location of the binding site(s). Labels that can be used are: radioactivity and fluorescence.Radioactivity has been traditionally used to label DNA fragments for footprinting analysis, as the method was originally developed from the Maxam-Gilbert chemical sequencing technique.