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In 2002, Mayo Clinic researchers identified a humoral mechanism, targeting a perivascular protein, as the culprit of NMO, [26] and in 2004 an unknown specific autoantibody was found. [79] In 2005 they identified the aquaporin 4 protein as the target of the disease, and developed the first in-house test to aid in the diagnosis of NMO by ...
Solitary sclerosis: This variant was proposed (2012) by Mayo Clinic researchers. [58] though it was also reported by other groups more or less at the same time. [59] [60] It is defined as isolated demyelinating lesions which produce a progressive myelopathy similar to primary progressive MS.
Clear cell sarcoma is a sub-type of a rare form of cancer called a sarcoma. [1] It is known to occur mainly in the soft tissues and dermis.Rare forms were thought to occur in the gastrointestinal tract before they were discovered to be different and redesignated as gastrointestinal neuroectodermal tumors.
A study examining over 4,000 biopsied skin lesions identified clinically as seborrheic keratoses showed 3.1% were malignancies. Two-thirds of those were squamous cell carcinoma . [ 11 ] To date, the gold standard in the diagnosis of seborrheic keratosis is represented by the histolopathologic analysis of a skin biopsy .
Spinal nerve sheath tumors generally arise as single lesions. [1] Presence of multiple lesions is associated with genetic conditions including neurofibromatosis type 1, neurofibromatosis type 2, and Schwannomatosis. [1] [3] [4] Most spinal schwannomas are intradural-extramedullary, growing inside the thecal sac, but outside the spinal cord ...
Treatment options for idiopathic pulmonary fibrosis are very limited, since no current treatment has stopped the progression of the disease. Because of this, there is no evidence that any medication can significantly help this condition, despite ongoing research trials. Lung transplantation is the only therapeutic option available in severe cases.