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B-cell linker (BLNK) protein is expressed in B cells and macrophages and plays a large role in B cell receptor signaling. [5] Like all adaptor proteins , BLNK has no known intrinsic enzymatic activity. [ 6 ]
A B-cell receptor includes both CD79 and the immunoglobulin. The plasma membrane of a B cell is indicated by the green phospholipids. The B- cell receptor extends both outside the cell (above the plasma membrane) and inside the cell (below the membrane). The B-cell receptor (BCR) is a transmembrane protein on the surface of a B cell.
B cell activation occurs in the secondary lymphoid organs (SLOs), such as the spleen and lymph nodes. [1] After B cells mature in the bone marrow, they migrate through the blood to SLOs, which receive a constant supply of antigen through circulating lymph. [14] At the SLO, B cell activation begins when the B cell binds to an antigen via its BCR ...
10673 24099 Ensembl ENSG00000102524 ENSMUSG00000031497 UniProt Q9Y275 Q9WU72 RefSeq (mRNA) NM_001145645 NM_006573 NM_033622 NM_001347309 RefSeq (protein) NP_001139117 NP_006564 NP_001334238 NP_296371 Location (UCSC) Chr 13: 108.25 – 108.31 Mb Chr 8: 10.06 – 10.09 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse B-cell activating factor (BAFF) also known as tumor necrosis factor ...
Linker of activated T cells, a protein in the biochemical signaling path transferring signals from T cell antigen receptors; B-cell linker, a human gene that encodes a linker protein related to B cells; Linker peptide, a flexible part of a peptide between relatively rigid structural domains.
27278 Ensembl ENSG00000109684 ENSMUSG00000039315 UniProt Q7Z7G1 Q9QZE2 RefSeq (mRNA) NM_052964 NM_013748 RefSeq (protein) NP_443196 NP_038776 Location (UCSC) Chr 4: 10.49 – 10.68 Mb Chr 5: 38.86 – 39.03 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cytokine dependent hematopoietic cell linker is a protein that in humans is encoded by the CLNK gene. Function MIST is a member of ...
V(D)J recombination (variable–diversity–joining rearrangement) is the mechanism of somatic recombination that occurs only in developing lymphocytes during the early stages of T and B cell maturation. It results in the highly diverse repertoire of antibodies/immunoglobulins and T cell receptors (TCRs) found in B cells and T cells, respectively.
Mechanism of class-switch recombination that allows isotype switching in activated B cells. Immunoglobulin class switching, also known as isotype switching, isotypic commutation or class-switch recombination (CSR), is a biological mechanism that changes a B cell's production of immunoglobulin from one type to another, such as from the isotype IgM to the isotype IgG. [1]