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Citicoline may have neuroprotective effects due to its preservation of cardiolipin and sphingomyelin, preservation of arachidonic acid content of phosphatidylcholine and phosphatidylethanolamine, partial restoration of phosphatidylcholine levels, and stimulation of glutathione synthesis and glutathione reductase activity.
An α7 nicotinic agonist appears to have positive effects on neurocognition in persons with schizophrenia. [8] Activation of α7 nicotinic acetylcholine receptor on mast cells, is a mechanism by which nicotine enhances atherosclerosis. [9] Both α4β2 and α7 nicotinic receptors appear to be critical for memory, working memory, learning, and ...
PHA-543,613 is a drug that acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors, with a high level of brain penetration and good oral bioavailability.
A neuron observed under an optical microscope. Neuroprotection refers to the relative preservation of neuronal structure and/or function. [1] In the case of an ongoing insult (a neurodegenerative insult) the relative preservation of neuronal integrity implies a reduction in the rate of neuronal loss over time, which can be expressed as a differential equation.
Previous research has found that "walking 1,000 extra steps per day can provide protective effects on their cardiovascular health,” Goodwin, an assistant investigator at the Feinstein Institutes ...
A cerebroprotectant (formerly known as a neuroprotectant) is a drug that is intended to protect the brain after the onset of acute ischemic stroke. [1] As stroke is the second largest cause of death worldwide and a leading cause of adult disability, over 150 drugs have been tested in clinical trials to provide cerebroprotection.