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Pimecrolimus is an immunosuppressant drug of the calcineurin inhibitor class used in the treatment of atopic dermatitis (eczema). It is available as a topical cream. It was developed and formerly marketed by Novartis under the trade name Elidel .
Topical pimecrolimus is often used in treating corticosteroid induced perioral dermatitis due to it being a non-steroid based cream. Pimecrolimus is generally well tolerated with a rare side effect of a burning sensation at the application site. [27]
Red burning skin syndrome from topical steroids. Typical pattern on lower arms and hands. Topical steroid addiction (TSA) is characterised by uncontrollable, spreading dermatitis and worsening skin inflammation, which requires a stronger topical steroid to get the same result as the first prescription.
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Tacrolimus and a related drug for eczema (pimecrolimus) were suspected of carrying a cancer risk, though the matter is still a subject of controversy. The FDA issued a health warning in March 2005 for the drug, based on animal models and a small number of patients.
An open-label pilot study found that topical pimecrolimus cream helped dark-skinned patients with postinflammatory hypopigmentation related to seborrheic dermatitis. [ 8 ] When functional melanocytes are present in the damaged area, sun or ultraviolet (UV) exposure may aid in repigmentation; however, excessive exposure may intensify the color ...
"The ascomycin macrolactam pimecrolimus (Elidel, SDZ ASM 981) is a potent inhibitor of mediator release from human dermal mast cells and peripheral blood basophils". The Journal of Allergy and Clinical Immunology. 108 (2): 275–280. doi: 10.1067/mai.2001.116865. PMID 11496246. Mollison KW, Fey TA, Krause RA, Thomas VA, Mehta AP, Luly JR (June ...
The same person as above shows no signs of balanitis circinata during a treatment with pimecrolimus. Balanitis circinata is one out of multiple manifestations of the reactive arthritis. [citation needed] Right now, topical corticosteroid therapy is the most commonly used treatment, and topical calcineurin inhibitors have also been used ...