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The anterior pituitary (also called the adenohypophysis or pars anterior) is a major organ of the endocrine system.The anterior pituitary is the glandular, anterior lobe that together with the (posterior pituitary, or the neurohypophysis) makes up the pituitary gland (hypophysis) which, in humans, is located at the base of the brain, protruding off the bottom of the hypothalamus.
The pouch eventually loses its connection with the pharynx giving rise to the anterior pituitary. The anterior wall of Rathke's pouch proliferates, filling most of the pouch to form pars distalis and pars tuberalis. The posterior wall forms pars intermedia. In some organisms, the proliferating anterior wall does not fully occupy Rathke's pouch ...
The anterior pituitary is typically divided into two regions, a more anterior rostral portion and a posterior proximal portion, but the boundary between the two is often not clearly marked. In elasmobranchs, there is an additional, ventral lobe beneath the anterior pituitary proper. [27]
A Rathke's cleft cyst is a benign growth on the pituitary gland in the brain, specifically a mucin-filled [1] cyst in the posterior portion of the anterior pituitary gland. [2] [3] It occurs when the Rathke's pouch does not develop properly and ranges in size from 2 to 40 mm in diameter.
Craniopharyngioma is a rare, usually suprasellar [15] neoplasm, which may be cystic, that develops from nests of epithelium derived from Rathke's pouch. [16] [17] Rathke's pouch is an embryonic precursor of the anterior pituitary. [citation needed] Craniopharyngiomas are typically very slow-growing tumors.
The protein Annexin A1 (ANXA1), found in high quantities in the anterior pituitary gland, is located specifically in the folliculostellate cell. [1] In addition to the anterior pituitary gland, it can also be found in the non-endocrine cells of the hypothalamus. Glucocorticoids act on the folliculostellate cells to increase synthesis of ANXA1 ...
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The cells of the anterior pituitary express specific G protein-coupled receptors that bind to the neuropeptides, activating intracellular second messenger cascades that produce the release of anterior pituitary hormones. [4] The following is a list of hormones that rely on the hypophyseal portal system to indirectly mediate their function by ...