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Chloroquine, in overdose, has a risk of death of about 20%. [24] It is rapidly absorbed from the gut with an onset of symptoms generally within an hour. [ 25 ] Symptoms of overdose may include sleepiness, vision changes, seizures , stopping of breathing , and heart problems such as ventricular fibrillation and low blood pressure .
The cause of dysentery is usually the bacteria from genus Shigella, in which case it is known as shigellosis, or the amoeba Entamoeba histolytica; then it is called amoebiasis. [1] Other causes may include certain chemicals, other bacteria, other protozoa, or parasitic worms. [2] It may spread between people. [4]
Shigellosis, known historically as dysentery, is an infection of the intestines caused by Shigella bacteria. [1] [3] Symptoms generally start one to two days after exposure and include diarrhea, fever, abdominal pain, and feeling the need to pass stools even when the bowels are empty. [1]
It is sometimes listed as an explicit differential diagnosis of bacillary dysentery, as opposed to a cause. [6] Bacillary dysentery should not be confused with diarrhea caused by other bacterial infections. One characteristic of bacillary dysentery is blood in stool, [7] which is the result of invasion of the mucosa by the pathogen.
In asymptomatic infections, the amoeba lives by eating and digesting bacteria and food particles in the gut, a part of the gastrointestinal tract. [9] It does not usually come in contact with the intestine itself due to the protective layer of mucus that lines the gut. Disease occurs when amoeba comes in contact with the cells lining the intestine.
The condition is usually caused by Gram-positive enteric commensal bacteria of the gut (). Clostridioides difficile is a species of Gram-positive bacteria that commonly causes severe diarrhea and other intestinal diseases when competing bacteria are wiped out by antibiotics, causing pseudomembranous colitis, whereas Clostridium septicum is responsible for most cases of neutropenic enterocolitis.
Plesiomonas shigelloides is a species of bacteria [1] and the only member of its genus. It is a Gram-negative, rod-shaped bacterium which has been isolated from freshwater, freshwater fish, shellfish, cattle, goats, swine, cats, dogs, monkeys, vultures, snakes, toads and humans. [2] It is considered a fecal coliform.
The two most common manifestations of E histolytica include colitis (bloody stool with mucus, abdominal pain, and/or diarrhea), and discovery of a liver abscess on imaging. [2] Liver abscesses commonly present as right upper quadrant abdominal pain and fever, with worsening features associated with abscess rupture.