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Other serious side effects include an increased risk of future cancer and pancreatitis. [2] Those with a genetic deficiency in thiopurine S-methyltransferase are at higher risk of side effects. [2] Use in pregnancy may harm the baby. [2] Mercaptopurine is in the thiopurine and antimetabolite family of medications. [4] [3]
Common side effects when used orally include itchiness and rash. [7] Common side effects when used by injection include vomiting and kidney problems. [7] While not recommended historically, starting allopurinol during an attack of gout appears to be safe. [8] [9] In those already on the medication, it should be continued even during an acute ...
Maintenance therapy with azathioprine or 6-mercaptopurine may lead people with active Crohn's to take less steroid medication. This may lower side effects related to steroid treatments. [9] Fistulizing disease [11] Maintenance of remission after surgery for Crohn's disease [12]
The association between inflammatory conditions of the eye and Crohn's disease is due to many Crohn's disease patients having genetic markers such as HLA-B07, HLA-B27 and HLA-DRB1*0103. [57] Additionally, cytokines IL-6, IL-10, and IL-17 which are produced in the bowel enter the circulatory system and travel to the eyes to trigger inflammation.
Azathioprine treatment is associated with an increased risk of lymphoma, but whether this is due to the drug or a predisposition related to Crohn's disease is unclear. [21] Lower doses of azathioprine are used as a therapy in children with refractory or corticosteroid-dependent Crohn's disease, without causing many side effects. [22]
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Northeast: Maine, Massachusetts, New Hampshire, New York, Vermont. No significant snowfall is forecast. Temperatures will be warmer than average, especially in April (3 degrees Fahrenheit above ...
Physicians tell the difference between Crohn's disease and UC by the location and nature of the inflammatory changes. Crohn's can affect any part of the gastrointestinal tract, from mouth to anus (skip lesions), although a majority of the cases start in the terminal ileum. Ulcerative colitis, in contrast, is restricted to the colon and the ...