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Orosomucoid (ORM) or alpha-1-acid glycoprotein (α 1 AGp, [1] AGP or AAG) is an acute phase protein found in plasma. It is an alpha-globulin glycoprotein and is modulated by two polymorphic genes. It is synthesized primarily in hepatocytes and has a normal plasma concentration between 0.6–1.2 mg/mL (1–3% plasma protein). [ 2 ]
Phenoxybenzamine has a long-lasting action, binding covalently to the alpha receptors. Its only current clinical use is in preparing patients with pheochromocytoma for surgery; its irreversible antagonism and the resultant depression in the maximum of the agonist dose-response curve are desirable in a situation where surgical manipulation of ...
Over the last 40 years, a variety of drugs have been developed from non-selective alpha-1 receptor antagonists to selective alpha-1 antagonists and alpha-1 receptor inverse agonists. [ 2 ] [ 3 ] The first drug that was used was a non-selective alpha blocker, named phenoxybenzamine and was used to treat BPH. [ 2 ]
Alpha-1 antitrypsin deficiency (A1AD or AATD) is a genetic disorder that may result in lung disease or liver disease. [1] Onset of lung problems is typically between 20 and 50 years of age. [ 1 ] This may result in shortness of breath , wheezing , or an increased risk of lung infections .
Mechanism of Action of Alpha -1 blocker. Alpha 1 blocker exerts its action on alpha-1 receptor, dilating the smooth muscles. [3] Alpha-1 receptor is a Gq type G-protein coupled receptor. [3] When it is activated, it will lead to activation of phospholipase C, raising the intracellular level of IP3 and DAG. [3]
Basic drugs will bind to the acidic alpha-1 acid glycoprotein. This is significant because various medical conditions may affect the levels of albumin, alpha-1 acid glycoprotein, and lipoproteins. This is significant because various medical conditions may affect the levels of albumin, alpha-1 acid glycoprotein, and lipoproteins.
Positive acute-phase proteins serve (as part of the innate immune system) different physiological functions within the immune system.Some act to destroy or inhibit growth of microbes, e.g., C-reactive protein, mannose-binding protein, [3] complement factors, ferritin, ceruloplasmin, serum amyloid A and haptoglobin.
18407 Ensembl ENSG00000229314 ENSMUSG00000028359 UniProt P02763 Q63805 RefSeq (mRNA) NM_000607 NM_013623 NM_001379520 NM_001379521 RefSeq (protein) NP_000598 n/a Location (UCSC) Chr 9: 114.32 – 114.33 Mb Chr 4: 63.27 – 63.28 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Alpha-1-acid glycoprotein 1 is a protein that in humans is encoded by the ORM1 gene. This gene encodes a key ...