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  2. Generally recognized as safe and effective - Wikipedia

    en.wikipedia.org/wiki/Generally_recognized_as...

    Generally recognized as safe and effective (abbreviated as GRASE, GRAS/E, or GRAS/GRAE) is designation for certain old drugs that do not require prior approval from the U.S. Food and Drug Administration in order to enter the United States marketplace because they are generally recognized as safe and effective by medical professionals.

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