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Progressive multifocal leukoencephalopathy (PML) is a rare and often fatal viral disease characterized by progressive damage (-pathy) or inflammation of the white matter (leuko-) of the brain (-encephalo-) at multiple locations (multifocal). It is caused by the JC virus, which is normally present and kept under control by the immune system. The ...
A CT of leukoencephalopathy. Leukoencephalopathy (leukodystrophy-like diseases) is a term that describes all of the brain white matter diseases, whether their molecular cause is known or unknown. [1]
Hepatitis A, adults > 50 years old Viral Unvaccinated ≈1.8% [17]: 278 Coronavirus disease 2019 (COVID-19) Viral Unvaccinated & Treated with unspecific treatments: 0.5-2% Depends largely on the age group of the person, earlier strains of COVID-19 had higher CFR of around 2%. [53] [54] [55] Lassa fever: Viral Treated ≈1%
Toxic leukoencephalopathy is a rare condition that is characterized by progressive damage (-pathy) to white matter (-leuko-) in the brain (-encephalo-), particularly myelin, due to causes such as exposure to substance use, environmental toxins, or chemotherapeutic drugs. The prevalence of this disease is infrequent and often goes unreported ...
As the years progressed, more accounts of similar patients with similar symptoms were documented; however no one classified all the accounts as the same disease. It was not until 1993-94 when Dr. Hanefeld and Dr. Schiffmann and their colleagues identified the disease as childhood-onset progressive leukoencephalopathy. They determined it was ...
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In 2016, the WHO recorded 56.7 million deaths [3] with the leading cause of death as cardiovascular disease causing more than 17 million deaths (about 31% of the total) as shown in the chart to the side. In 2021, there were approx. 68 million deaths worldwide, as per WHO report.
Leukoencephalopathies such as progressive multifocal leukoencephalopathy; Leukodystrophies; The myelinoclastic disorders are typically associated with symptoms such as optic neuritis and transverse myelitis, because the demyelinating inflammation can affect the optic nerve or spinal cord. Many are idiopathic.