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  2. Proton-pump inhibitor - Wikipedia

    en.wikipedia.org/wiki/Proton-pump_inhibitor

    The proton pump is the terminal stage in gastric acid secretion, being directly responsible for secreting H + ions into the gastric lumen, making it an ideal target for inhibiting acid secretion. [ citation needed ] Because the H,K-ATPase is the final step of acid secretion, an inhibitor of this enzyme is more effective than receptor ...

  3. Drugs for acid-related disorders - Wikipedia

    en.wikipedia.org/wiki/Drugs_for_acid-related...

    The H 2 receptor antagonists are a class of drugs used to block the action of histamine on parietal cells in the stomach, decreasing the production of acid by these cells. H 2 antagonists are used in the treatment of dyspepsia, although they have been surpassed in popularity by the more effective [1] proton pump inhibitors.

  4. Discovery and development of proton pump inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    Proton pump inhibitors (PPIs) block the gastric hydrogen potassium ATPase (H + /K + ATPase) and inhibit gastric acid secretion. These drugs have emerged as the treatment of choice for acid-related diseases, including gastroesophageal reflux disease (GERD) and peptic ulcer disease. PPIs also can bind to other types of proton pumps such as those ...

  5. Pantoprazole - Wikipedia

    en.wikipedia.org/wiki/Pantoprazole

    Pantoprazole, sold under the brand name Protonix, among others, is a medication used for the treatment of stomach ulcers, short-term treatment of erosive esophagitis due to gastroesophageal reflux disease (GERD), maintenance of healing of erosive esophagitis, and pathological hypersecretory conditions including Zollinger–Ellison syndrome.

  6. Rabeprazole - Wikipedia

    en.wikipedia.org/wiki/Rabeprazole

    Rabeprazole, sold under the brand name Aciphex, among others, is a medication that decreases stomach acid. [6] It is used to treat peptic ulcer disease, gastroesophageal reflux disease, and excess stomach acid production such as in Zollinger–Ellison syndrome. [6]

  7. Ranitidine - Wikipedia

    en.wikipedia.org/wiki/Ranitidine

    Ranitidine, previously sold under the brand name Zantac [a] among others, is a medication used to decrease stomach acid production. [12] It was commonly used in treatment of peptic ulcer disease, gastroesophageal reflux disease, and Zollinger–Ellison syndrome. [12] It can be given by mouth, injection into a muscle, or injection into a vein.