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Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, migraines, or surgery. [8] It is also effective for treating gastroenteritis .
Common side effects include dizziness, tiredness, joint pain, low blood pressure, nausea, and shortness of breath. [5] Severe side effects may include bronchospasm. [5] Safety during pregnancy or breastfeeding is unclear. [6] Use is not recommended in those with liver problems. [7] Carvedilol is a nonselective beta blocker and alpha-1 blocker. [5]
The therapeutic window (or pharmaceutical window) of a drug is the range of drug dosages which can treat disease effectively without having toxic effects. [18] Medication with a small therapeutic window must be administered with care and control, frequently measuring blood concentration of the drug, to avoid harm.
Ali stresses that everyone responds to medication like Ozempic differently, but most won’t benefit from very low doses. “Some folks may be very sensitive, but that’s unusual,” he says.
There are few side effects related to the use of 5-HT 3 antagonists; the most common are constipation or diarrhea, headache, and dizziness. [28] Unlike antihistamines with antiemetic properties such as cyclizine , 5-HT 3 antagonists do not produce sedation , nor do they cause extrapyramidal effects , as phenothiazines (such as prochlorperazine ...
Tricyclics have a narrow therapeutic index, i.e., the therapeutic dose is close to the toxic dose. [7] Factors that increase the risk of toxicity include advancing age, cardiac status, and concomitant use of other drugs. [8] However, serum drug levels are not useful for evaluating risk of arrhythmia or seizure in tricyclic overdose. [9]
Typically a dose ranging study will include a placebo group of subjects, and a few groups that receive different doses of the test drug. For instance, a typical dose-ranging study may include four groups: a placebo group, low-dose group, medium-dose group and a high-dose group. The maximum tolerable dose (MTD) information is necessary to be ...
In the 0.075mg and 0.15mg doses, the mother monkeys ate less, lost weight, and didn’t gain as much weight as usual during pregnancy. Researchers also noted birth defects in the bones of the baby ...