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Schaffer collaterals are axon collaterals given off by CA3 pyramidal cells in the hippocampus.These collaterals project to area CA1 of the hippocampus [1] and are an integral part of memory formation and the emotional network of the Papez circuit, and of the hippocampal trisynaptic loop.
In mice, the projection to CA1, and the subiculum all come primarily from EC layer III. [citation needed]According to Suh et al. (2011 Science 334:1415) the projection to CA3 and dentate gyrus in mice is primarily from layer II of entorhinal cortex, and forms a trisynaptic path with hippocampus (dentate gyrus to CA3 to CA1), distinguished from the direct (monosynaptic) perforant path from ...
Axon reinnervation is greatly affected by the pathway the regenerated nerve has chosen to grow along. The nerves' ability to properly function after damage is very dependent on successful reinnervation, which is why the effects of PMR are so relevant. The success of nerve reinnervation after different grafting attempts is a current research ...
Established collateral branches, like the main axon, exhibit a growth cone and develop independently of the main axon tip. Overall, axon elongation is the product of a process known as tip growth. In this process, new material is added at the growth cone while the remainder of the axonal cytoskeleton remains stationary.
An axon can divide into many branches called telodendria (Greek for 'end of tree'). At the end of each telodendron is an axon terminal (also called a terminal bouton or synaptic bouton, or end-foot). [20] Axon terminals contain synaptic vesicles that store the neurotransmitter for release at the synapse. This makes multiple synaptic connections ...
Association fibers are axons (nerve fibers) that connect cortical areas within the same cerebral hemisphere. [1]In human neuroanatomy, axons within the brain, can be categorized on the basis of their course and connections as association fibers, projection fibers, and commissural fibers. [1]
Guillain–Barré syndrome – nerve damage. Neuroregeneration in the peripheral nervous system (PNS) occurs to a significant degree. [5] [6] After an injury to the axon, peripheral neurons activate a variety of signaling pathways which turn on pro-growth genes, leading to reformation of a functional growth cone and regeneration.
Axon guidance (also called axon pathfinding) is a subfield of neural development concerning the process by which neurons send out axons to reach their correct targets. Axons often follow very precise paths in the nervous system, and how they manage to find their way so accurately is an area of ongoing research.