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[16] [17] The demand for mice generated at The Jackson Lab increased in 1937 when the Surgeon General supported a grant from National Cancer Institute to the lab that made mice produced there a de facto industry standard due to federal standardization requirements because it was the only large-scale mouse provider before World War II. [17]
The NSG mouse (NOD scid gamma mouse) is a brand of immunodeficient laboratory mice, developed and marketed by Jackson Laboratory, which carries the strain NOD.Cg-Prkdc scid Il2rg tm1Wjl /SzJ. NSG branded mice are among the most immunodeficient described to date. [1] NSG branded mice lack mature T cells, B cells, and natural killer (NK) cells. [2]
The Jackson Laboratory in Bar Harbor, Maine is currently one of the world's largest suppliers of laboratory mice, at around 3 million mice a year. [5] The laboratory is also the world's source for more than 8,000 strains of genetically defined mice and is home of the Mouse Genome Informatics database. [6]
It is "the authoritative source of official names for mouse genes, alleles, and strains", which follow the guidelines established by the International Committee on Standardized Genetic Nomenclature for Mice. [6] The history and focus of Jackson Laboratory research and production facilities generates tremendous knowledge and depth which ...
In 1970, of the sensitive mice from that breeding, some were found to be susceptible to Friend leukaemia virus. These mice were bred into the modern FVB strain at the Jackson Laboratory, with no subsequent selection for histamine sensitivity.
The first ob/ob mouse arose by chance in a colony at the Jackson Laboratory in 1949. [1] The mutation is recessive. Mutant mice are phenotypically indistinguishable from their unaffected littermates at birth, but gain weight rapidly throughout their lives, reaching a weight three times that of unaffected mice.
Funding for the Jackson Laboratory was extremely limited during the Great Depression, but it received one of the first grants from the newly formed National Cancer Institute in 1938. Little energetically developed both the lab and the ACS, and by 1944 they were shipping 9000 mice a week to other laboratories.
Once a strain of mice had been first described in published research, mice were stored and acquired through Jackson Laboratory, a nonprofit research institute. The patenting of OncoMouse, and the breadth of the claims made in those patents, were considered to be unreasonable by many of their contemporaries. [ 4 ]