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Apixaban is a highly selective, orally bioavailable, and reversible direct inhibitor of free and clot-bound factor Xa. Factor Xa catalyzes the conversion of prothrombin to thrombin, the final enzyme in the coagulation cascade that is responsible for fibrin clot formation. [27]
A social insurance number (SIN) (French: numéro d'assurance sociale (NAS)) is a number issued in Canada to administer various government programs. The SIN was created in 1964 to serve as a client account number in the administration of the Canada Pension Plan and Canada's varied employment insurance programs.
[40] [41] Numbers with 666 or 900–999 (Individual Taxpayer Identification Number) in the first digit group. [40] Until 2011, the SSA published the last group number used for each area number. [42] Because group numbers were allocated in a regular pattern, it was possible to identify an unissued SSN that contained an invalid group number.
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Full funding is a desirable goal for private pension plans as well, but is often not achieved. Social insurance programs are often not fully funded, and some argue that full funding is not economically desirable. [17] Most international systems of social insurance are funded on an ongoing basis without reference to future liabilities.
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A trigonometric number is a number that can be expressed as the sine or cosine of a rational multiple of π radians. [2] Since sin ( x ) = cos ( x − π / 2 ) , {\displaystyle \sin(x)=\cos(x-\pi /2),} the case of a sine can be omitted from this definition.
The form is GYYMMDDSSSC, where G shows the person's sex and century of birth (odd number male, even number female, 1-2 19th century, 3-4 20th century, 5-6 21st century), YYMMDD is the person's date of birth, SSS is a serial number separating persons born on the same date, and C is a checksum.
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