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Linear IgA bullous dermatosis is a rare immune-mediated blistering skin disease frequently associated with medication exposure, especially vancomycin, with men and women being equally affected. [ 2 ] : 135 It was first described by Tadeusz Chorzelski in 1979 and may be divided into two types: [ 3 ] : 587
A vesiculobullous disease is a type of mucocutaneous disease characterized by vesicles and bullae (i.e. blisters).Both vesicles and bullae are fluid-filled lesions, and they are distinguished by size (vesicles being less than 5–10 mm and bulla being larger than 5–10 mm, depending upon which definition is used).
It can appear similar to porphyria cutanea tarda, pemphigoid, pemphigus, dermatitis herpetiformis, or blistering drug eruption. [3] The condition is longterm and has no cure. [1] A good response may be seen with corticosteroids, either alone or combined with azathioprine or dapsone. [3]
Epidermolysis bullosa simplex is caused by genetic mutations that prevent the proper formation of protein structures in the skin’s epidermis.
Bullous pemphigoid (a type of pemphigoid) is an autoimmune pruritic skin disease that typically occurs in people aged over 60, that may involve the formation of blisters in the space between the epidermal and dermal skin layers.
Grover's disease is mainly seen in males over the age of forty. [13] Grover's disease affects chiefly white adults in the fifth decade or later, and appears to be around 1.6 to 2.1 times more common in men than in women. Grover's disease appears less commonly in darker-skinned individuals. [citation needed] [9]
A rare and severe variation of fixed drug eruption, generalized bullous fixed drug eruption involves blisters and erosions involving at least 10% of the body's surface area, affecting three of the six anatomic sites: the head and neck, the anterior and posterior trunk, the upper and lower extremities, and the genitalia. [4]
The culprit can be both a prescription drug or an over-the-counter medication. Examples of common drugs causing drug eruptions are antibiotics and other antimicrobial drugs, sulfa drugs , nonsteroidal anti-inflammatory drugs (NSAIDs), biopharmaceuticals , chemotherapy agents, anticonvulsants and psychotropic drugs .
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