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Phenibut is used in Russia, Ukraine, Belarus and Latvia as a pharmaceutical drug to treat anxiety and to improve sleep (e.g., in the treatment of insomnia). [5] [6] It is also used for various other indications, including the treatment of asthenia, depression, alcoholism, alcohol withdrawal syndrome, post-traumatic stress disorder, stuttering, tics, vestibular disorders, Ménière's disease ...
The drug is a GABA analogue and is closely related to baclofen (β-(4-chlorophenyl)-GABA), tolibut (β-(4-methylphenyl)-GABA), and phenibut (β-phenyl-GABA). [1] It is less potent as a GABA B receptor agonist than baclofen but more potent than phenibut.
Phenibut (Anvifen, Fenibut, Noofen) is an anxiolytic [42] used in Russia. [43] Phenibut is a GABA B receptor agonist , [ 42 ] as well as an antagonist at α 2 δ subunit -containing voltage-dependent calcium channels (VDCCs), similarly to gabapentinoids like gabapentin and pregabalin . [ 44 ]
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While any illegal trade in a medication should be a concern, there is scant evidence that Suboxone is being used as a gateway to drug use in the U.S. Addicts say taking the medication just helps them feel normal again.
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Polysubstance use or multisubstance use is the use of combinations of psychoactive substances with both legal and illegal substances. This page lists polysubstance combinations that are entheogenic , recreational , or off-label indicated use of pharmaceuticals.
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