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The RPI is used to assess whether the bone marrow is producing an appropriate response to an anemic state. Reticulocyte production should increase in response to any loss of red blood cells. It should increase within 2–3 days of a major acute hemorrhage, for instance, and reach its peak in 6–10 days. [3]
A reticulocyte percentage that is higher than "normal" can be a sign of anemia, but this depends on the health of a person's bone marrow. Calculating the reticulocyte production index is an important step in understanding whether or not the reticulocyte count is appropriate to the situation. This is often a more important question than whether ...
In response to significant blood loss, either acute (e.g., trauma or surgery) or chronic (e.g., gastrointestinal bleeding), the bone marrow increases production to replace lost red blood cells. This results in an increased reticulocyte count, as new immature cells are released and make up a larger proportion of the blood volume. [2]
The reticulocyte production index (RPI) or corrected reticulocyte count (CRC) represents the true significance of the absolute reticulocyte count to provide some reflection of erythropoietic demand and supply. The immature reticulocyte fraction (IRF) goes a step further to cast more light on the same question. [citation needed]
Reticulocyte production often recovers within one week. Parvovirus infection in people reliant on frequent red cell production due to low baseline production or high turnover rates are at risk of developing a life-threatening condition called aplastic crisis (see below).
A reticulocyte count that is high, normal or low will aid with the classification process. A high reticulocyte count signifies that bone marrow processes are normal. A low reticulocyte count would signify there is a problem at the level of the bone marrow, which produce the stem cells. Acute blood loss would result in a high reticulocyte count ...
For non-megaloblastic macrocytic anemias, a reticulocyte count may be helpful. Non-megaloblastic macrocytic anemias with a low reticulocyte count (indicating a poor bone marrow response to the anemia) suggest liver disease (e.g., cirrhosis), hypothyroidism, toxic effects of alcohol on the bone marrow, or myelodysplasia. [1]
Reticulocyte count - Reticulocytes are elevated when the infant is producing more blood to combat anemia. [2] A rise in the retic count can mean that an infant may not need additional transfusions. [37] Low retic is observed in infants treated with IUT and in those with HDN from anti-Kell [36]