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Sézary disease, or Sézary syndrome, [1] is a type of cutaneous T-cell lymphoma that was first described by Albert Sézary. [2] The affected T cells, known as Sézary's cells or Lutzner cells, have pathological quantities of mucopolysaccharides. Sézary disease is sometimes considered a late stage of mycosis fungoides with lymphadenopathy. [3] [4]
An accumulation of Lutzner cells in the layers of the skin can cause cutaneous T-cell lymphoma. Cutaneous cell lymphoma is the second most common form of non-Hodgkin's lymphoma. [ 11 ] Two forms of cutaneous T-cell lymphoma associated with abnormal T-lymphocytes or Lutzner cells are Mycosis Fungoides and Sézary Syndrome. [ 12 ]
Cutaneous T-cell lymphoma (CTCL) is a class of non-Hodgkin lymphoma, which is a type of cancer of the immune system.Unlike most non-Hodgkin lymphomas (which are generally B-cell-related), CTCL is caused by a mutation of T cells.
Legg–Calvé–Perthes disease; Legius syndrome; Leiner's disease; Lelis syndrome; Lemierre's syndrome; Lennox–Gastaut syndrome; Lenz microphthalmia syndrome; Lenz–Majewski syndrome; Leriche's syndrome; Leschke syndrome; Lesch–Nyhan syndrome; Lethal congenital contracture syndrome; Lethal white syndrome
T-PLL is an extremely rare aggressive disease, and patients are not expected to live normal lifespans. Before the recent introduction of better treatments, such as alemtuzumab, the median survival time was 7.5 months after diagnosis. [7] More recently, some patients have survived five years and more, although the median survival is still low.
The T cell variations are usually caused by the prolonged use of T cell suppressant drugs, such as sirolimus, tacrolimus, or ciclosporin. [2] The Epstein-Barr virus , which infects >90% of the world population, is also a common cause of these disorders, being responsible for a wide range of non-malignant, pre-malignant, and malignant Epstein ...
Ménière's disease causes hearing fluctuations in the affected ear. During an episode of vertigo, hearing loss typically worsens and the ability to hear clearly in the affected ear may be ...
This is an uncommon skin disease and is a benign collection of lymph cells. Its cause is not known and can be hereditary. [1]: 1887 [2]: 727 It is named for Max Jessner. [3] [4] It is thought to be equivalent to lupus erythematosus tumidus. [5]