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Serine proteases (or serine endopeptidases) are enzymes that cleave peptide bonds in proteins. Serine serves as the nucleophilic amino acid at the (enzyme's) active site. [1] They are found ubiquitously in both eukaryotes and prokaryotes. Serine proteases fall into two broad categories based on their structure: chymotrypsin-like (trypsin-like ...
Serpin A12 (OL-64, Vaspin, Visceral adipose-specific serpin, Ser A12) is a glycoprotein that is a class A member of the serine protease inhibitor family. [5] In humans, Serpin A12 is encoded by the SERPINA12 gene.
Factor D is a serine protease present in blood and tissue in an active sequence but self-inhibited conformation. The only known natural substrate of Factor D is Factor B, and cleavage of the Arg 234-Lys 235 scissile bond in Factor B results in two Factor B fragments, Ba and Bb.
This gene encodes a member of the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor class A domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases ...
Serine protease HTRA1 is an enzyme that in humans is encoded by the HTRA1 gene. [ 5 ] [ 6 ] The HTRA1 protein is composed of four distinct protein domains . They are from amino-terminus to carboxyl-terminus an Insulin-like growth factor binding domain, a kazal domain , a trypsin -like peptidase domain and a PDZ domain .
Only 1 viral member of the subtilisin family is known, a 56-kDa protease from herpes virus 1, which infects the channel catfish. [3] Sedolisins (serine-carboxyl peptidases) are proteolytic enzymes whose fold resembles that of subtilisin; however, they are considerably larger, with the mature catalytic domains containing approximately 375 amino ...
16612 Ensembl ENSG00000167748 ENSMUSG00000063903 UniProt P06870 P15947 RefSeq (mRNA) NM_002257 NM_010639 NM_001320331 NM_001320332 RefSeq (protein) NP_002248 NP_001307260 NP_001307261 NP_034769 Location (UCSC) Chr 19: 50.82 – 50.82 Mb Chr 7: 43.87 – 43.88 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Kallikrein-1 is a protein that in humans is encoded by the KLK1 gene. KLK1 is ...
Serine (symbol Ser or S) [3] [4] is an α-amino acid that is used in the biosynthesis of proteins. It contains an α- amino group (which is in the protonated − NH + 3 form under biological conditions), a carboxyl group (which is in the deprotonated − COO −