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Phosphatidylserine (PS) is the major acidic phospholipid class that accounts for 13–15% of the phospholipids in the human cerebral cortex. [7] In the plasma membrane, PS is localized exclusively in the cytoplasmic leaflet where it forms part of protein docking sites necessary for the activation of several key signaling pathways.
In enzymology, a CDP-diacylglycerol—serine O-phosphatidyltransferase (EC 2.7.8.8) is an enzyme that catalyzes the chemical reaction CDP-diacylglycerol + L-serine ⇌ {\displaystyle \rightleftharpoons } CMP + (3-sn-phosphatidyl)-L-serine
Phosphatidylserine decarboxylase is the enzyme that is used to decarboxylate phosphatidylserine in the first pathway. The phosphatidylserine decarboxylation pathway is the main source of synthesis for phosphatidylethanolamine in the membranes of the mitochondria. Phosphatidylethanolamine produced in the mitochondrial membrane is also ...
L-serine-phosphatidylethanolamine phosphatidyltransferase (EC 2.7.8.29, phosphatidylserine synthase 2, serine-exchange enzyme II, PTDSS2 (gene)) is an enzyme with systematic name L-1-phosphatidylethanolamine:L-serine phosphatidyltransferase. [1] [2] This enzyme catalyses the following chemical reaction
Lecithins are mixtures of glycerophospholipids including phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, and phosphatidic acid. [3] Lecithin was first isolated in 1845 by the French chemist and pharmacist Théodore Gobley. [4] In 1850, he named the phosphatidylcholine lécithine. [5]
The conversion of PA into diacylglycerol (DAG) by LPPs is the commitment step for the production of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and phosphatidylserine (PS). In addition, DAG is also converted into CDP-DAG, which is a precursor for phosphatidylglycerol (PG), phosphatidylinositol (PI) and phosphoinositides (PIP, PIP 2 ...