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The Let-7 microRNA precursor gives rise to let-7, a microRNA (miRNA) involved in control of stem-cell division and differentiation. [1] let-7, short for "lethal-7", was discovered along with the miRNA lin-4 in a study of developmental timing in C. elegans, [2] making these miRNAs the first ever discovered.
Molecular biology / m ə ˈ l ɛ k j ʊ l ər / is a branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions.
A multi-omics study introduced a new molecular classification of GIST and identifies YLPM1, a potential tumor suppressor gene [9]. The study categorised KIT/PDGFRA-mutated GISTs into 4 molecular subtypes. The C2 subtype, enriched with CD8+ T cells, shows potential responsiveness to immunotherapy. [10]
This suggests that life could not have arisen in its current form, which has led researchers to hypothesize mechanisms whereby the current system might have arisen from a simpler precursor system. [14] American molecular biologist Alexander Rich was the first to posit a coherent hypothesis on the origin of nucleotides as precursors of life. [15]
Molecular Biology of the Cell has been described as "the most influential cell biology textbook of its time". [2] The sixth edition is dedicated to the memory of co-author Julian Lewis, who died in early 2014. The book was the first to position cell biology as a central discipline for biology and medicine, and immediately became a landmark ...
MBE publishes patterns and processes that impact the evolution of life at molecular levels, across a full breadth of taxonomy, genomic organization, and functions, forms, and phenotypes. MBE's Methods, Resource, and Protocol sections include research tools that enable discoveries, while the Reviews and Perspectives synthesize different aspects ...
Molecular evolution describes how inherited DNA and/or RNA change over evolutionary time, and the consequences of this for proteins and other components of cells and organisms. Molecular evolution is the basis of phylogenetic approaches to describing the tree of life. Molecular evolution overlaps with population genetics, especially on shorter ...
Molecular medicine is a broad field, where physical, chemical, biological, bioinformatics and medical techniques are used to describe molecular structures and mechanisms, identify fundamental molecular and genetic errors of disease, and to develop molecular interventions to correct them. [1]