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The area under the effect curve (AUEC) is an integral of the effect of a drug over time, estimated as a previously-established function of concentration. It was proposed to be used instead of AUC in animal-to-human dose translation, as computer simulation shows that it could cope better with half-life and dosing schedule variations than AUC.
Simpson's rules are used to calculate the volume of lifeboats, [6] and by surveyors to calculate the volume of sludge in a ship's oil tanks. For instance, in the latter, Simpson's 3rd rule is used to find the volume between two co-ordinates. To calculate the entire area / volume, Simpson's first rule is used. [7]
Fitting of a noisy curve by an asymmetrical peak model, with an iterative process (Gauss–Newton algorithm with variable damping factor α).Curve fitting [1] [2] is the process of constructing a curve, or mathematical function, that has the best fit to a series of data points, [3] possibly subject to constraints.
The area formula can be used in calculating the volume of a partially-filled cylindrical tank lying horizontally. In the design of windows or doors with rounded tops, c and h may be the only known values and can be used to calculate R for the draftsman's compass setting.
In qualitative terms, a line integral in vector calculus can be thought of as a measure of the total effect of a given tensor field along a given curve. For example, the line integral over a scalar field (rank 0 tensor) can be interpreted as the area under the field carved out by a particular curve.
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The area of each block is the fraction of the total that each category represents, and the total area of all the bars is equal to 1 (the fraction meaning "all"). The curve displayed is a simple density estimate. This version shows proportions, and is also known as a unit area histogram.
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