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  2. Acute monocytic leukemia - Wikipedia

    en.wikipedia.org/wiki/Acute_monocytic_leukemia

    Acute monocytic leukemia (AMoL, or AML-M5) [2] is a type of acute myeloid leukemia. In AML-M5 >80% of the leukemic cells are of monocytic lineage. [3] This cancer is characterized by a dominance of monocytes in the bone marrow. There is an overproduction of monocytes that the body does not need in the periphery.

  3. Leukemia - Wikipedia

    en.wikipedia.org/wiki/Leukemia

    In addition to these genetic issues, people with chromosomal abnormalities or certain other genetic conditions have a greater risk of leukemia. [47] For example, people with Down syndrome have a significantly increased risk of developing forms of acute leukemia (especially acute myeloid leukemia ), and Fanconi anemia is a risk factor for ...

  4. Gene therapy for blood diseases - Wikipedia

    en.wikipedia.org/wiki/Gene_therapy_for_blood...

    The CARs are designed to recognize the specific cancer antigens and bind to them, allowing T-cells to target and attack the cancer cells. The genetically modified T-cells are administered back to the patients as a treatment. Leukemia is a group of blood cancers commonly found in children younger than 15 and elders older than 55. [3]

  5. Chronic lymphocytic leukemia - Wikipedia

    en.wikipedia.org/wiki/Chronic_lymphocytic_leukemia

    It most commonly affects individuals over the age of 65, due to the accumulation of genetic mutations that occur over time. [3] [18] CLL is rarely seen in individuals less than 40 years old. [19] Men are more commonly affected than women, although the average lifetime risk for both genders are similar (around 0.5-1%) .

  6. Acute lymphoblastic leukemia - Wikipedia

    en.wikipedia.org/wiki/Acute_lymphoblastic_leukemia

    Additional common genetic changes in B-cell ALL involve non-inherited mutations to PAX5 and IKZF1. [2] In T-cell ALL, LYL1, TAL1, TLX1, and TLX3 rearrangements can occur. [4] Acute lymphoblastic leukemia results when enough of these genetic changes are present in a single lymphoblast.

  7. T-cell acute lymphoblastic leukemia - Wikipedia

    en.wikipedia.org/wiki/T-cell_acute_lymphoblastic...

    However, because there are fewer cases of T-ALL compared to other subtypes of leukemia, the exact cause(s) (i.e. etiology) of T-ALL remains unclear. T-ALL is neither contagious nor inherited, but specific genetic mutations (commonly including those in NOTCH1 and CDKN2A) may be passed along, increasing susceptibility to cases of T-ALL. [10]