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G6PD converts G6P into 6-phosphoglucono-δ-lactone and is the rate-limiting enzyme of the pentose phosphate pathway. Thus, regulation of G6PD has downstream consequences for the activity of the rest of the pentose phosphate pathway. Glucose-6-phosphate dehydrogenase is stimulated by its substrate G6P.
G6PD deficiency results from mutations in the G6PD gene. G6PD gene contributes to the production of glucose-6-phosphate dehydrogenase. Chemical reactions involving glucose-6-phosphate dehydrogenase produce compounds that prevent reactive oxygen species from building up to toxic levels within red blood cells. If a reduction in the amount of ...
People suffering from 6PGD or G6PD deficiency (or both) are at risk of hemolytic anemia in states of oxidative stress. Oxidative stress can result from infection and from chemical exposure to medication and certain foods. Broad beans, e.g., fava beans, contain high levels of vicine, divicine, convicine and isouramil, all of which are oxidants.
G6PD deficient red cells in combination with high levels of oxidants causes a cross-linking of sulfhydryl groups on globin chains which causes a denaturing and formation of Heinz body precipitates. [8] Heinz bodies can also be found in chronic liver disease. [9] Alpha-thalassemia. Normal adult hemoglobin is composed of two alpha and two beta ...
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The logo of King To Nin Jiom (read from right to left) King-to Nin Jiom Pei Pa Koa (Chinese: 京都 念 慈 菴 川 貝 枇杷 膏; Jyutping: ging1 dou1 nim6 ci4 am1 cyun1 bui3 pei4 paa4 gou1; pinyin: Jīngdū niàn cí ān chuānbèi pípá gāo), commonly known as Nin Jiom Pei Pa Koa or simply Nin Jiom Herbal Cough Syrup, is a traditional Chinese natural herbal remedy used for the relief of ...
Yardlong bean, illustration from the Japanese agricultural encyclopedia Seikei Zusetsu (1804). The asparagus bean (Vigna unguiculata subsp. sesquipedalis) is a legume cultivated for its edible green pods containing immature seeds, like the green bean. [1]
Plasmodium vivax is a protozoal parasite and a human pathogen.This parasite is the most frequent and widely distributed cause of recurring malaria. [2] Although it is less virulent than Plasmodium falciparum, the deadliest of the five human malaria parasites, P. vivax malaria infections can lead to severe disease and death, often due to splenomegaly (a pathologically enlarged spleen).