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If these effects found in rodents carry over to humans, even minimal exposure to BPA could cause an increased risk for breast cancer. [81] The elevated incidence of breast cancer in women has been associated with prolonged exposure to high levels of estrogens. Xenoestrogens such as BPA have the capacity to perturb normal hormonal actions.
Estrogen receptors are over-expressed in around 70% of breast cancer cases, referred to as "ER-positive", and can be demonstrated in such tissues using immunohistochemistry. Two hypotheses have been proposed to explain why this causes tumorigenesis, and the available evidence suggests that both mechanisms contribute:
Estradiol, the major estrogen sex hormone in humans. Neurodegenerative diseases can disrupt the normal human homeostasis and result in abnormal estrogen levels. For example, neurodegenerative diseases can cause different physiological effects in males and females.
About 80% of breast cancers feed off estrogen; therefore, suppression of this hormone is routinely recommended for treatment. The associated symptoms that come with losing the hormone are accepted ...
Initially, I was wary about using an estrogen product because my breast cancer was hormone sensitive, but he reaffirmed that the research regarding topical estrogen and breast cancer risk shows ...
As for the notion that certain types of HRT might increase the risk of breast cancer, Dr. Nichols says there’s no strong clinical evidence linking hormone replacement therapy to increased cancer ...
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