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3586 16153 Ensembl ENSG00000136634 ENSMUSG00000016529 UniProt P22301 P18893 RefSeq (mRNA) NM_000572 NM_010548 RefSeq (protein) NP_000563 NP_034678 Location (UCSC) Chr 1: 206.77 – 206.77 Mb Chr 1: 130.95 – 130.95 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti- inflammatory cytokine ...
Pegylation prolongs the half-life of the bound protein, leading to sustained delivery. [4] [6] [7] [8] This is advantageous because lower, less frequent dosing will be needed to have the same therapeutic effect in the patient, which will limit the cytotoxicity of the delivery system. [6] [7] Pegfilgrastim is a successful example of this ...
CXCL10 is secreted by several cell types in response to IFN-γ.These cell types include monocytes, endothelial cells and fibroblasts. [5] CXCL10 has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and ...
Interferon gamma (IFNG or IFN-γ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. [5] The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulated with phytohemagglutinin, and by others as a product of antigen-stimulated lymphocytes. [6]
Interleukin-15 (IL-15) is a protein that in humans is encoded by the IL15 gene.IL-15 is an inflammatory cytokine with structural similarity to Interleukin-2 (IL-2). Like IL-2, IL-15 binds to and signals through a complex composed of IL-2/IL-15 receptor beta chain and the common gamma chain (gamma-C, CD132).
It was also estimated that the half-life of memory B cells was between 8–10 weeks, after doing an experiment in which the cells were treated in vivo with bromodeoxyuridine. [15] In other experiments in mouse, it has been shown that the lifespan of memory B cells is at least 9 times greater than the lifespan of a follicular naïve B cell. [16]
5008 18413 Ensembl ENSG00000099985 ENSMUSG00000058755 UniProt P13725 P53347 RefSeq (mRNA) NM_020530 NM_001319108 NM_001013365 RefSeq (protein) NP_001306037 NP_065391 NP_001013383 Location (UCSC) Chr 22: 30.26 – 30.27 Mb Chr 11: 4.19 – 4.19 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Oncostatin M, also known as OSM, is a protein that in humans is encoded by the OSM gene. OSM ...
16183 Ensembl ENSG00000109471 ENSMUSG00000027720 UniProt P60568 P04351 RefSeq (mRNA) NM_000586 NM_008366 RefSeq (protein) NP_000577 NP_032392 Location (UCSC) Chr 4: 122.45 – 122.46 Mb Chr 3: 37.17 – 37.18 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin-2 (IL-2) is an interleukin, which is a type of cytokine signaling molecule forming part of the immune system. It is a ...