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Collagenous colitis is an inflammatory condition of the colon.Together with the related condition lymphocytic colitis, it is a subtype of microscopic colitis, which is characterized by inflammation that specifically affects the colon (i.e. colitis), and a clinical presentation that involves watery diarrhea but a lack of rectal bleeding.
Incidence and prevalence of microscopic colitis nears those of ulcerative colitis and Crohn's disease. [11] Studies in North America found incidence rates of 7.1 per 100,000 person-years and 12.6 per 100,000 person-years for collagenous colitis for lymphocytic colitis, respectively. [11] Prevalence has been estimated as 103 cases per 100,000 ...
Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions. SSRIs increase the extracellular level of the neurotransmitter serotonin by limiting its reabsorption (reuptake) into the ...
No definite cause has been determined. The peak incidence of lymphocytic colitis is in persons over age 50; the disease affects twice as many women as men. [3] Some reports have implicated long-term usage of NSAIDs, proton pump inhibitors, and selective serotonin reuptake inhibitors, and other drugs.
SSRIs are modern antidepressants often used as a first-line treatment for major depressive disorder. Common SSRIs include Prozac (fluoxetine), Zoloft (sertraline) and Lexapro (escitalopram).
For example, cocaine, which non-selectively inhibits the reuptake of serotonin, norepinephrine, and dopamine, is an SRI but not an SSRI. SRIs are used predominantly as antidepressants (e.g., SSRIs, SNRIs, and TCAs), though they are also commonly used in the treatment of other psychological conditions such as anxiety disorders and eating disorders.