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Lactocillin is a thiopeptide antibiotic which is encoded for and produced by biosynthetic genes clusters in the bacteria Lactobacillus gasseri. Lactocillin was discovered and purified in 2014. [1] Lactobacillus gasseri is one of the four Lactobacillus bacteria found to be most common in the human vaginal microbiome. [2]
The primary colonizing bacteria of a healthy individual are of the genus Lactobacillus (90–95%), the most common being L. crispatus, L. iners, L. jensenii, and L. gasseri. [5] Since the first description of lactobacilli by Döderlein, lactobacilli have been generally considered the gatekeepers of the vaginal ecosystem.
Lactobacillus gasseri is a species in the genus Lactobacillus identified in 1980 by François Gasser and his associates. [ 1 ] [ 2 ] L. gasseri is a normal inhabitant of the intestines and lower reproductive tract in healthy women . [ 3 ]
Lactobacillus jensenii is a lactic acid bacteria species in the genus Lactobacillus. It is one of the four main species of Lactobacillus considered to be the major part of the vaginal flora, along with Lactobacillus crispatus, Lactobacillus gasseri, and Lactobacillus iners. [1] [2] L. jensenii is sometimes used in producing fermented foods. [3]
TMP/SMX is commonly used due to its ability to achieve high concentrations in urinary tract tissues and urine. This antibiotic combination demonstrates notable efficacy in both the treatment and prophylaxis of recurrent urinary tract infections. [12] Common adverse effects include nausea, vomiting, rash,pruritus, and photosensitivity. [26]
VMB is dominated mainly by Lactobacillus species. This is the list of organisms that are found in the lower reproductive tract of sexually mature women who are not immunocompromised . A partial description of pathogens that can be found in the lower and upper reproductive tract of women can be found in the article sexually transmitted infection .