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Evolutionary Theories of Aging and Longevity; The Evolutionary Theory of Aging by João Pedro de Magalhães. Programmed-Aging.Org Site provides comprehensive information on programmed ageing, the programmed/non-programmed controversy, and underlying evolution controversies.
Genetic theories of aging propose that aging is programmed within each individual's genes. According to this theory, genes dictate cellular longevity. Programmed cell death, or apoptosis , is determined by a "biological clock" via genetic information in the nucleus of the cell.
This is an accepted version of this page This is the latest accepted revision, reviewed on 2 February 2025. Biological process of getting older This article is about ageing specifically in humans. For the ageing of whole organisms including animals, see Senescence. For other uses, see Ageing (disambiguation). Part of a series on Human growth and development Stages Gamete Zygote Embryo Fetus ...
All evolutionary theories of aging rest on the basic mechanisms that the force of natural selection declines with age. [19] [20] Mechanistic theories of aging can be divided into theories that propose aging is programmed, and damage accumulation theories, i.e. those that propose aging to be caused by specific molecular changes occurring over time.
The metabolic stability theory of aging suggests it is the cells ability to maintain stable concentration of ROS which is the primary determinant of lifespan. [37] This theory criticizes the free radical theory because it ignores that ROS are specific signalling molecules which are necessary for maintaining normal cell functions. [37]
Selectivity theory (aging) Socioemotional selectivity theory; Stage-crisis view; Stem cell theory of aging; Stereotype embodiment theory; T. Telomere theory of aging; V.
In biogerontology, the disposable soma theory of aging states that organisms age due to an evolutionary trade-off between growth, reproduction, and DNA repair maintenance. [1] Formulated by British biologist Thomas Kirkwood , the disposable soma theory explains that an organism only has a limited amount of resources that it can allocate to its ...
The reliability theory of aging is an attempt to apply the principles of reliability theory to create a mathematical model of senescence.The theory was published in Russian by Leonid A. Gavrilov and Natalia S. Gavrilova as Biologiia prodolzhitelʹnosti zhizni in 1986, and in English translation as The Biology of Life Span: A Quantitative Approach in 1991.