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Heat shock proteins (HSPs) are a family of proteins produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock, [1] but are now known to also be expressed during other stresses including exposure to cold, [2] UV light [3] and during wound healing or tissue remodeling. [4]
Heat shock proteins are also believed to play a role in the presentation of pieces of proteins (or peptides) on the cell surface to help the immune system recognize diseased cells. [22] The major HSPs involved in the HSR include HSP70, HSP90, and HSP60. [5] Chaperones include the HSP70s and HSP90s while HSP60s are considered to be chaperonins. [17]
3320 15519 Ensembl ENSG00000080824 ENSMUSG00000021270 UniProt P07900 P07901 RefSeq (mRNA) NM_001017963 NM_005348 NM_010480 RefSeq (protein) NP_001017963 NP_005339 NP_034610 Location (UCSC) Chr 14: 102.08 – 102.14 Mb Chr 12: 110.66 – 110.67 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Heat shock protein HSP 90-alpha is a protein that in humans is encoded by the HSP90AA1 gene ...
Heat shock protein beta-6 (HSPB6) is a protein that in humans is encoded by the HSPB6 gene. [5] [6] [7]HSPB6 is a 17-kDa member of the heat shock family of proteins. HSPB6 was first identified in 1994 when it was isolated from rat and human skeletal muscle as a complex with HSPB1 (also known as HSP27) and HSPB5 (also known as αB-crystallin).
8988 56534 Ensembl ENSG00000169271 ENSMUSG00000051456 UniProt Q12988 Q9QZ57 RefSeq (mRNA) NM_006308 NM_019960 RefSeq (protein) NP_006299 NP_064344 Location (UCSC) Chr 5: 54.46 – 54.46 Mb Chr 13: 113.8 – 113.8 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Heat shock protein beta-3 (HspB3) also known as heat shock 27kDa protein 3 is a protein that in humans is encoded by the ...
Heat shock 70 kDa protein 1L is a protein that in humans is encoded by the HSPA1L gene on chromosome 6. [ 5 ] [ 6 ] [ 7 ] As a member of the heat shock protein 70 ( Hsp70 ) family and a chaperone protein , it facilitates the proper folding of newly translated and misfolded proteins, as well as stabilize or degrade mutant proteins.
3297 15499 Ensembl ENSG00000185122 ENSG00000284774 ENSMUSG00000022556 UniProt Q00613 P38532 RefSeq (mRNA) NM_005526 NM_008296 RefSeq (protein) NP_005517 NP_001318081 NP_001318082 NP_001318083 NP_001318143 NP_032322 Location (UCSC) Chr 8: 144.29 – 144.31 Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse Heat shock factor protein 1 (HSF 1) is a protein that in humans is encoded by ...
Heat Shock Protein Family B (small) member 7 (HSPB7) in humans is a protein encoded by a gene of the same name with four exons that is located on chromosome 1p36.13. [ 4 ] , . [ 5 ] HSPB7 contains 170 amino acids and has a molecular weight of 18,611 Da . [ 6 ]