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Symptoms including blurring or loss of vision, headache, and (rarely) stroke or coma are due to the effects of the IgM paraprotein, which may cause autoimmune phenomena or cryoglobulinemia. Other symptoms of Waldenström macroglobulinemia are due to hyperviscosity syndrome, which is present in 6–20% of patients.
Waldenström macroglobulinemia is a slow-silent disease that typically develops when a person is around 65 or older, is male, has a family history of lymphoma, and is caucasian. [6] The condition is called Waldenström macroglobulinemia because the abnormal cells generate excessive levels of IgM which is the biggest immunoglobulin protein, and ...
Waldenström first described, in 1944, patients with a disease that has subsequently been named for him, Waldenström's macroglobulinemia, a "hyperviscosity syndrome" in which symptoms are caused by abnormal lymphocytes that prevent normal bone marrow function, which causes anemia and hepatosplenomegaly, and secrete large immunoglobulins ...
The Golden Bachelor’s Gerry Turner is opening up about a recent medical diagnosis. He told People that he was diagnosed with a slow-growing blood marrow cancer in early 2024.. The news comes ...
Waldenström's macroglobulinemia transforms white blood cells into cancer cells which build up in the bone marrow, ... according to the Mayo Clinic. The disease is most common in males over age 70.
Symptoms can include swollen but painless lymph nodes, unexplained fever, and unintended weight loss. [2] There are several subtypes, the most common of which is follicular lymphoma. Others include cutaneous T-cell lymphoma, marginal zone lymphoma, chronic lymphocytic leukemia, and Waldenström macroglobulinemia. [2]
“We are encouraged by the emerging positive data from NX-5948 in patients with Waldenstrom’s macroglobulinemia, which add to the previously disclosed robust clinical activity observed in patients with chronic lymphocytic leukemia,” said Paula G. O’Connor, M.D., chief medical officer of Nurix.
Bing–Neel syndrome (BNS) is an extremely rare neurologic complication of Waldenström macroglobulinemia (WM), which is a chronic lymphoproliferative disorder. [1] There's no clear definition of BNS but what is known so far is that unlike WM, It involves the central nervous system (CNS), infiltrated by differentiated malignant B cells and by having hyperglobulinemia. [2]