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Symptoms including blurring or loss of vision, headache, and (rarely) stroke or coma are due to the effects of the IgM paraprotein, which may cause autoimmune phenomena or cryoglobulinemia. Other symptoms of Waldenström macroglobulinemia are due to hyperviscosity syndrome, which is present in 6–20% of patients.
Waldenström first described, in 1944, patients with a disease that has subsequently been named for him, Waldenström's macroglobulinemia, a "hyperviscosity syndrome" in which symptoms are caused by abnormal lymphocytes that prevent normal bone marrow function, which causes anemia and hepatosplenomegaly, and secrete large immunoglobulins ...
Waldenström macroglobulinemia is a slow-silent disease that typically develops when a person is around 65 or older, is male, has a family history of lymphoma, and is caucasian. [6] The condition is called Waldenström macroglobulinemia because the abnormal cells generate excessive levels of IgM which is the biggest immunoglobulin protein, and ...
About 1,000 to 1,500 Americans are diagnosed with WM annually, and it's more common in men than in women. The chances of developing the condition increase with age, with the average age of ...
Hyperviscosity syndrome is a group of symptoms triggered by an increase in the viscosity of the blood.Symptoms of high blood viscosity include spontaneous bleeding from mucous membranes, visual disturbances due to retinopathy, and neurologic symptoms ranging from headache and vertigo to seizures and coma.
Others include cutaneous T-cell lymphoma, marginal zone lymphoma, chronic lymphocytic leukemia, and Waldenström macroglobulinemia. [2] Indolent lymphoma accounts for 41 percent of all non-Hodgkin lymphoma cases in North America and Northern Europe. It mainly affects older adults, and affects men and women almost equally. [4]
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