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Many medical devices and products come into contact with the internal surfaces of the body, such as surgical tools and implants. When a non-native material enters the body, the first step of the immune response takes place and host extracellular matrix and plasma proteins aggregate to the material in attempts to contain, neutralize, or wall-off the injurious agent. [1]
Protein patterning – chessboard pattern. Biomaterials are materials that are used in contact with biological systems. Biocompatibility and applicability of surface modification with current uses of metallic, polymeric and ceramic biomaterials allow alteration of properties to enhance performance in a biological environment while retaining bulk properties of the desired device.
Protein adsorption influences the interactions that occur at the tissue-implant interface. Protein adsorption can lead to blood clots, the foreign-body response and ultimately the degradation of the device. In order to counter-act the effects of protein adsorption, implants are often coated with a polymer coating to decrease protein adsorption.
The adsorption of these compounds changes how the material interacts with the body and can improve biocompatibility. In titanium alloys such as Ti-Zr and Ti-Nb, zirconium and niobium ions that are liberated due to corrosion are not released into the patient's body, but rather added to the passivation layer. [ 10 ]
This is necessary because the human hip is acted on by approximately 10–12 times the body weight and therefore the bone cement must absorb the forces acting on the hips to ensure that the artificial implant remains in place over the long term. Bone cement chemically is nothing more than Plexiglas (i.e. polymethyl methacrylate or PMMA). [1]
Orthopedic implant example seen with X-ray. An orthopedic implant is a medical device manufactured to replace a missing joint or bone, or to support a damaged bone. [1] The medical implant is mainly fabricated using stainless steel and titanium alloys for strength and the plastic coating that is done on it acts as an artificial cartilage. [2]
An implant is a medical device manufactured to replace a missing biological structure, support a damaged biological structure, or enhance an existing biological structure. For example, an implant may be a rod, used to strengthen weak bones. Medical implants are human-made devices, in contrast to a transplant, which is a transplanted biomedical ...
Implant creation sequence: CT scan to CAD to 3D printed titanium cranial implant. Alloplasty is a method for synthetic implants to be inserted into the body to aid physical and mental function. [3] [14] The procedure can be performed to reconstruct defects such as cranial defects. [15]