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Hypericum perforatum, commonly known as St John's wort (sometimes perforate St John's wort or common St John's wort), is a flowering plant in the family Hypericaceae.It is a perennial plant that grows up to 1 metre (3 ft 3 in) tall, with many yellow flowers that have clearly visible black glands around their edges, long stamens (male reproductive organs), and three pistils (female reproductive ...
Hyperforin is a phytochemical produced by some of the members of the plant genus Hypericum, notably Hypericum perforatum (St John's wort). [2] Hyperforin may be involved in the pharmacological effects of St. John's wort, [2] specifically in its antidepressant effects. [3] [4] [5]
One meta-analysis found that St John's wort had similar efficacy and safety as prescriptions drugs to treat mild-to-moderate depression, such as selective serotonin reuptake inhibitors. [ 16 ] There is evidence that combining St. John’s wort with prescription antidepressants may cause adverse effects , such as a life-threatening increase of ...
Hypericum scouleri, known by the common name Scouler's St. John's wort in English, is a flowering species of plant from western North America. It grows in areas around streams and wetlands from Canada to the highlands of Mexico. It is sometimes mistaken for the invasive Perforate St John's wort from Eurasia.
Hypericin is a naphthodianthrone, an anthraquinone derivative which, together with hyperforin, is one of the principal active constituents of Hypericum (Saint John's wort). [2] [3] Hypericin is believed to act as an antibiotic, antiviral [2] and non-specific kinase inhibitor.
Hypericum yezoense [a], the Yezo St John's wort, is a species of flowering plant in the St John's wort family Hypericaceae. Native to Japan, Sakhalin, and the Kurils, the plant can be found among rocks and in grasslands. It is a perennial herb with many stems and small flower clusters.
St John's wort: Tipton's weed, Klamath weed Hypericum perforatum: Photosensitization, [3] [15] GI disturbances, "allergic reactions, fatigue, dizziness, confusion, dry mouth" [15] Valerian: garden valerian, garden heliotrope, all-heal Valeriana officinalis "drowsiness, GI upset, headache, palpitations, insomnia", [3] oversedation ...
A 2017 meta-analysis found ... Inducers of cytochrome P450 enzymes like CYP3A4 such as St. John's wort, ... There is an interaction between estradiol and alcohol such ...