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While at UCL Clark wrote the first edition of his textbook Applied Pharmacology [13] in 1923, a book that was to be updated by two of his successors as Head of department, first by H.O. Schild and later by H.P. Rang, and is still extant in the form of the widely used textbook Rang & Dale's Pharmacology. [14]
The therapeutic index (TI; also referred to as therapeutic ratio) is a quantitative measurement of the relative safety of a drug with regard to risk of overdose.It is a comparison of the amount of a therapeutic agent that causes toxicity to the amount that causes the therapeutic effect. [1]
Martindale aims to cover drugs and related substances reported to be of clinical interest anywhere in the world. It provides health professionals with a useful source of information to identify medicines, such as confirming the drug and brand name of a medication being taken by a patient arriving from abroad.
Agents that "bind" to the toxin can reduce free or active toxin present. It is possible for this binding to be nonspecific or specific. Activated charcoal is the non-specific binding agent most frequently utilised as it has strong adsorption capacity and could prevent the toxin's enterohepatic recirculation.
The IUPHAR/BPS Guide to PHARMACOLOGY is an open-access website, acting as a portal to information on the biological targets of licensed drugs and other small molecules. The Guide to PHARMACOLOGY (with GtoPdb being the standard abbreviation) is developed as a joint venture between the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS).
Dale also began authoring his own works, including Pharmacologia in 1693, which was a well received textbook of pharmacology and therapeutics. Samuel Dale contributed nine papers to the Philosophical Transactions of the Royal Society including the first account of the strata and fossils of Harwich cliff .
In pharmacology, an effective dose (ED) or effective concentration (EC) is the dose or concentration of a drug that produces a biological response. [1] [2] The term "effective dose" is used when measurements are taken in vivo, while "effective concentration" is used when the measurements are taken in vitro.
In neuroscience, Dale's principle (or Dale's law) is a rule attributed to the English neuroscientist Henry Hallett Dale. The principle basically states that a neuron performs the same chemical action at all of its synaptic connections to other cells, regardless of the identity of the target cell. However, there has been disagreement about the ...