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Urinary casts are microscopic cylindrical structures produced by the kidney and present in the urine in certain disease states. They form in the distal convoluted tubule and collecting ducts of nephrons , then dislodge and pass into the urine, where they can be detected by microscopy .
Acute tubular necrosis is classified as a "renal" (i.e. not pre-renal or post-renal) cause of acute kidney injury. Diagnosis is made by a FENa (fractional excretion of sodium) > 3% and presence of muddy casts (a type of granular cast) in urinalysis.
Infective endocarditis - Infection that affects the inner lining of the heart (endocardium) and can potentially cause a thrombus to form on one or more heart valves and, if left untreated, can cause septic emboli that can have many systemic effects, including deposition into the glomerulus, causing glomerulonephritis and nephritic syndrome. [25]
Hypocitraturia or low urinary-citrate excretion (variably defined as less than 320 mg/day) can be a contributing cause of kidney stones in up to 2/3 of cases. The protective role of citrate is linked to several mechanisms; citrate reduces urinary supersaturation of calcium salts by forming soluble complexes with calcium ions and by inhibiting ...
Myeloma cast nephropathy, also referred to as light-chain cast nephropathy, is the formation of plugs (urinary casts) in the kidney tubules from free immunoglobulin light chains leading to kidney failure in the context of multiple myeloma. It is the most common cause of kidney injury in myeloma.
"The particular bacteria that are responsible for 80 percent or so of these urinary tract infections are a form of E. coli," said study co-author Edward Egelman in a video released by the ...
Examples of urinary casts: a) RTE cell cast, b) "muddy" granular cast, c) white blood cell cast, d) red blood cell cast [112] Urinary casts are cylindrical structures composed of Tamm-Horsfall glycoprotein. Their shape derives from the renal tubules where they are formed, and the protein base can incorporate cells or other material. Hyaline ...
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