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Salicylate toxicity also causes an uncoupling of oxidative phosphorylation and a decrease in citric acid cycle activity in the mitochondria. [9] This decrease in aerobic production of adenosine triphosphate (ATP) is accompanied by an increase in anaerobic production of ATP through glycolysis which leads to glycogen depletion and hypoglycemia. [ 9 ]
Salicylate intolerance is a form of food intolerance or of drug intolerance. Salicylate sensitivity is a pharmacological reaction, not a true IgE -mediated allergy. However, it is possible for aspirin to trigger non-allergic hypersensitivity reactions. [8][9] About 5–10% of asthmatics have aspirin hypersensitivity, but dietary salicylates ...
Salicylic acid is a phenolic phytohormone, and is found in plants with roles in plant growth and development, photosynthesis, transpiration, and ion uptake and transport. [53] Salicylic acid is involved in endogenous signaling, mediating plant defense against pathogens. [54]
The increased pH and larger surface area of the small intestine causes aspirin to be absorbed more slowly there, as more of it is ionized. Owing to the formation of concretions, aspirin is absorbed much more slowly during overdose, and plasma concentrations can continue to rise for up to 24 hours after ingestion. [58] [59] [60]
Long-term use (more than six weeks) may lead to accumulation and toxicity. [8] High daily intake over a period of months can possibly cause severe fatigue, weakness and neurological symptoms that reverse with discontinuation. [9] Some of the risks of salicylism can apply to the use of bismuth subsalicylate. [10] [11] [12]
Reye syndrome is a rapidly worsening brain disease. [2] Symptoms of Reye syndrome may include vomiting, personality changes, confusion, seizures, and loss of consciousness. [1] While liver toxicity typically occurs in the syndrome, jaundice usually does not. [2]
Salicylate poisoning tends to only occur when applied to a large area and in children. [2] Use is thus not recommended in children less than two years old. [2] It comes in a number of different strengths. [3] Salicylic acid overdose can lead metabolic acidosis with compensatory respiratory alkalosis. In people presenting with an acute overdose ...
Mechanism of action of aspirin. Tridimensional model of the chemical structure of aspirin. Aspirin causes several different effects in the body, mainly the reduction of inflammation, analgesia (relief of pain), the prevention of clotting, and the reduction of fever. Much of this is believed to be due to decreased production of prostaglandins ...