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Metronidazole is a well-known and commonly used anti-protozoal agent, but another 5-nitroimidazole derivative, ornidazole, may be preferable, where available, because of its longer half-life and fewer side-effects.
Metronidazole has well-known efficacy against intestinal protozoa and anaerobic bacteria. Ornidazole is a relatively new derivative with a 1.7-fold longer half-life than metronidazole, thus enabling its use as a single dose and promoting patient compliance with treatment, which is particularly crucial among children and the elderly [20].
Ornidazole vs. Metronidazole⁚ A Comparison. Ornidazole and Metronidazole are both nitroimidazole antimicrobial agents, but they have differences in their spectrum of activity and side effect profiles. Efficacy. The efficacy of Ornidazole and Metronidazole is comparable in treating anaerobic bacterial and protozoal infections.
Metronidazole 1.5 g daily for 5 days was given in three equal doses to adults, while 20 mg/kg was given to children aged 3–15 years. Ornidazole 2 g was given as a single dose to adults, and 30 mg/kg was given as a single dose to children.
A statistically significant difference was recorded between the efficacies of ornidazole and metronidazole, both parasitologically (92.9% vs. 69.6%, p 0.001) and clinically (96.4% vs....
Metronidazole is one of the mainstay drugs for the treatment of anaerobic bacterial infections, protozoal infections, and microaerophilic bacterial infections. It is cytotoxic to facultative anaerobic microorganisms.
Antimicrobial spectrum is similar to that of metronidazole and is more well tolerated; [1]: 1368 however there are concerns of lower relative efficacy. [ 3 ] It was first introduced for treating trichomoniasis before being recognized for its broad anti-protozoan and anti-anaerobic-bacterial capacities.