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Alpha-keratin (α-keratin) is a type of keratin found in vertebrates. It is the key structural material making up scales, hair, nails, feathers, horns, claws, hooves, and the outer layer of skin among vertebrates. Keratin also protects epithelial cells from damage or stress. Keratin is extremely insoluble in water and organic solvents.
Keratinocyte. Keratinocytes are the primary type of cell found in the epidermis, the outermost layer of the skin. In humans, they constitute 90% of epidermal skin cells. [1] Basal cells in the basal layer (stratum basale) of the skin are sometimes referred to as basal keratinocytes. [2] Keratinocytes form a barrier against environmental damage ...
Alpha-keratin. This protein is the primary component in hairs, horns, claws, nails and the epidermis layer of the skin. α-keratin is a fibrous structural protein, meaning it is made up of amino acids that form a repeating secondary structure. The secondary structure of α-keratin is very similar to that of a traditional protein α-helix and ...
Keratin is a crucial fibrous protein found in animals, constituting tough structures like hair, feathers, nails, and horns. It's classified based on tissue origin and sulfur content: soft keratins have lower sulfur, while hard keratins, found in hair and claws, contain more sulfur, creating a stronger structure. [2]
The cytoskeleton consists of (a) microtubules, (b) microfilaments, and (c) intermediate filaments. [1] The cytoskeleton is a complex, dynamic network of interlinking protein filaments present in the cytoplasm of all cells, including those of bacteria and archaea. [2] In eukaryotes, it extends from the cell nucleus to the cell membrane and is ...
Cytokeratin. Keratin intermediate filaments in epithelial cells (red stain). Cytokeratins are keratin proteins found in the intracytoplasmic cytoskeleton of epithelial tissue. They are an important component of intermediate filaments, which help cells resist mechanical stress. [1] Expression of these cytokeratins within epithelial cells is ...
The cytoplasm of its cells shows filamentous keratin. These corneocytes are embedded in a lipid matrix composed of ceramides, cholesterol, and fatty acids. [3] Desquamation is the process of cell shedding from the surface of the stratum corneum, balancing proliferating keratinocytes that form in the stratum basale. These cells migrate through ...
Keratin 5. Keratin 5, also known as KRT5, K5, or CK5, is a protein that is encoded in humans by the KRT5 gene. [5][6][7] It dimerizes with keratin 14 and forms the intermediate filaments (IF) that make up the cytoskeleton of basal epithelial cells. [8][9] This protein is involved in several diseases including epidermolysis bullosa simplex and ...