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In oncology, polycythemia vera (PV) is an uncommon myeloproliferative neoplasm in which the bone marrow makes too many red blood cells. [1] The majority of cases [2] are caused by mutations in the JAK2 gene, most commonly resulting in a single amino acid change in its protein product from valine to phenylalanine at position 617.
Polycythemia vera (PCV) (a.k.a. polycythemia rubra vera (PRV)) occurs when excess red blood cells are produced as a result of an abnormality of the bone marrow. [3] Often, excess white blood cells and platelets are also produced. A hallmark of polycythemia vera is an elevated hematocrit, with Hct > 55% seen in 83% of cases. [19]
Pityriasis rubra pilaris refers to a group of chronic disorders characterized by reddish orange, scaling plaques and keratotic follicular papules. [2]: 442 Symptoms may include reddish-orange patches (Latin: rubra) on the skin, severe flaking (Latin: pityriasis), uncomfortable itching, thickening of the skin on the feet and hands, and thickened bumps around hair follicles (Latin: pilus for hair).
Miliaria rubra is also known as prickly heat and heat rash. [6] Differential diagnosis should be used to rule out polycythemia vera, which is a rare hematological disorder and appears more often in males than females, generally not before the age of 40. Both disorders share a common trait of appearing after taking a hot shower.
Senile pruritus. Senile pruritus is one of the most common conditions in the elderly or people over 65 years of age with an emerging itch that may be accompanied with changes in temperature and textural characteristics. [1][2][3] In the elderly, xerosis, is the most common cause for an itch due to the degradation of the skin barrier over time. [4]
Pityriasis rosea. Pityriasis rosea is a type of skin rash. [2] Classically, it begins with a single red and slightly scaly area known as a "herald patch". [2] This is then followed, days to weeks later, by an eruption of many smaller scaly spots; pinkish with a red edge in people with light skin and greyish in darker skin. [4]
These bumps can appear as red, pink, brown, or your skin color. They are typically hard and round, symmetrical, and anywhere from half a centimeter to two centimeters wide. Plaques might also ...
981TME683S. KEGG. D11027. Ropeginterferon alfa-2b, sold under the brand name Besremi, is a medication used to treat polycythemia vera. [2][3][4][5] It is an interferon. [2][4] It is given by injection. [2][4] The most common side effects include low levels of white blood cells and platelets (blood components that help the blood to clot), muscle ...