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Common side effects include sleepiness, weakness, and dizziness. [8] Serious side effects, such as seizures and rhabdomyolysis, may occur if use of baclofen is stopped abruptly. [8] Use during pregnancy is of unclear safety, whilst use during breastfeeding is likely safe, and even more so if oral administration is avoided. [14]
Baclofen was first suggested as an adjunct because benzodiazepines do not affect GABA B receptors and therefore have no cross-tolerance with GHB while baclofen, which works via GABA B receptors, is cross-tolerant with GHB and may be more effective in alleviating withdrawal effects of GHB.
These adverse effects are believed to be due to the neurotoxic effects of repeated withdrawal from alcohol on aberrant neuronal plasticity and cortical damage. Repeated periods of acute intoxication followed by acute detoxification has profound effects on the brain and is associated with an increased risk of seizures as well as cognitive deficits.
As interest in taking glucagon-like peptide-1 receptor agonist (GLP-1 agonist) medications, such as Zepbound and Wegovy, for weight loss, research continues to examine potential new side effects ...
The most common side-effects of benzodiazepines are related to their sedating and muscle-relaxing action. They include drowsiness , dizziness, and decreased alertness and concentration. Lack of coordination may result in falls and injuries particularly in the elderly.
A study confirmed that side effects like pancreatitis and kidney damage are possible while taking GLP-1s like Ozempic. Here's what a doctor wants you to know.
Effectiveness appears similar to baclofen or diazepam. [4] It is taken by mouth. [5] Common side effects of tizanidine include dry mouth, sleepiness, weakness, and dizziness. [5] Serious side effects may include low blood pressure, liver problems, psychosis, and QT prolongation. [5] It is unclear if use in pregnancy and breastfeeding is safe. [6]
The side effects of the TCAs usually come to prominence before the therapeutic benefits against depression and/or anxiety do, and for this reason, they may potentially be somewhat dangerous, as volition can be increased, possibly giving the patient a greater desire to attempt or commit suicide.