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This list of protein subcellular localisation prediction tools includes software, databases, and web services that are used for protein subcellular localization prediction. Some tools are included that are commonly used to infer location through predicted structural properties, such as signal peptide or transmembrane helices , and these tools ...
Many prediction methods now exceed the accuracy of some high-throughput laboratory methods for the identification of protein subcellular localization. [ 1 ] [ 2 ] [ 3 ] Particularly, some predictors have been developed [ 4 ] that can be used to deal with proteins that may simultaneously exist, or move between, two or more different subcellular ...
Proteome Analyst (PA) is a freely available web server and online toolkit for predicting protein subcellular localization, or where a protein resides in a cell. [1] [2] In the field of proteomics, accurately predicting a protein's subcellular localization, or where a specific protein is located inside a cell, is an important step in the large scale study of proteins.
LocDB [1] is an expert-curated database that collects experimental annotations for the subcellular localization of proteins in Homo sapiens (human) and Arabidopsis thaliana (Weed). The database also contains predictions of subcellular localization from a variety of state-of-the-art prediction methods for all proteins with experimental information.
Motifs can, for example, be used to predict subcellular localization of a protein (where in the cell the protein is sent after synthesis). Short signal peptides direct certain proteins to a particular location such as the mitochondria, and various tools exist for the prediction of these signals in a protein sequence. [14]
PSORT is a bioinformatics tool used for the prediction of protein localisation sites in cells. [1] [2] It receives the information of an amino acid sequence and its taxon of origin (e.g. Gram-negative bacteria) as inputs. Then it analyses the input sequence by applying the stored rules for various sequence features of known protein sorting signals.
Bacteria also have subcellular localizations that can be separated when the cell is fractionated. The most common localizations referred to include the cytoplasm , the cytoplasmic membrane (also referred to as the inner membrane in Gram-negative bacteria), the cell wall (which is usually thicker in Gram-positive bacteria) and the extracellular ...
The Subcellular [7] section of the Human Protein Atlas provides high-resolution insights into the expression and spatiotemporal distribution of proteins encoded by 13147 genes (65% of the human protein-coding genes). For each gene, the subcellular distribution of the protein has been investigated by immunofluorescence (ICC-IF) and confocal ...